Atypical Proliferating Clear Cell Adenofibroma of the Ovary: A Case Report

♦Corresponding Author: Hena A. Ansari, MD Department of Pathology, Jawaharlal Nehru Medical College AMU, Aligarh-202002, UP, India Email: [email protected] Introduction Ovarian adenofibromas are characterized histologically by a prominent fibrous tissue component in addition to epithelial elements. They are classified by the World Health Organization according to epithelial type into serous, endometrioid, mucinous, clear cell and mixed categories and according to the degree of epithelial proliferation and atypia into benign, borderline and malignant variants.1 The epithelium is usually of the serous type. Tumors with epithelium composed of hobnail, cuboidal or columnar cells with abundant clear or eosinophilic cytoplasm are classified as clear cell type. Clear cell changes in ovarian tumors are usually associated with a malignant process; benign and borderline clear cell tumors are quite uncommon.1 There are only a few documented cases of clear cell adenofibromas, particularly with atypical histologic changes in the tumor epithelium. Compared to clear cell adenocarcinomas, borderline (atypical) clear cell tumors are very rare.2-5 Clear cell changes in adenofibromas have diagnostic implications as other ovarian tumors with clear cell changes, such as carcinomas, can be associated with these tumors and have to be considered in the differential Abstract Clear cell adenofibromas of borderline malignancy are extremely rare tumors of the ovaries. They may be associated with ovarian clear cell adenocarcinomas which typically present as large adnexal masses and are generally considered highly malignant. We describe the case of a postmenopausal female with an ovarian mass diagnosed as atypical (borderline) proliferating clear cell adenofibroma. The patient is alive and well without signs of recurrence three years after surgery.